Photo of Nilendu Gupta

Nilendu Gupta

  • Associate Professor, School of Health and Rehabilitation Sciences
    The Ohio State University
  • Associate Professor, Radiation Oncology
    The Ohio State University
  • Chief of Clinical Medical Physics
    The Ohio State University
  • Medical Physics Residency Program Director
    The Ohio State University
  • gupta.6@osu.edu
  • A201L James Cancer Hospital & Solove Research Institute
    Columbus, Ohio 43210
  • Most Common Publication Keywords # of Pubs
  • RADIOTHERAPY3
  • AAPM TG-61 REPORT1
  • ACUTE MYELOID-LEUKEMIA1
  • ADJUVANT TEMOZOLOMIDE1
  • ANGULAR DEPENDENCE1
  • ANISOTROPIC ANALYTICAL ALGORITHM1
  • ARCCHECK COMMISSIONING1
  • ARCCHECK DIODE ARRAY1
  • ARCCHECK EVALUATION1
  • BEAM DOSIMETRY1
  • Most Common Publication Subject Categories # of Pubs
  • RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING8
  • ONCOLOGY6
  • BIOLOGY1
  • CLINICAL NEUROLOGY1
  • MULTIDISCIPLINARY SCIENCES1
  • NUCLEAR SCIENCE & TECHNOLOGY1

Most Recent Journal Articles

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  • Majithia,Lonika; Rong,Yi; Siddiqui,Farzan; et al. "Treating cutaneous T-cell lymphoma with highly irregular surfaces with photon irradiation using rice as tissue compensator." Frontiers in oncology. Vol. 5, (Jan 2015): 49-?. (Published). Majithia,Lonika; Rong,Yi; Siddiqui,Farzan; Hattie,Todd; Gupta,Nilendu; Weldon,Michael; Chakravarti,Arnab; Wong,Henry,K; Porcu,Pierluigi; Xu-Welliver,Meng Treating cutaneous T-cell lymphoma with highly irregular surfaces with photon irradiation using rice as tissue compensator. Frontiers in oncology Journal Article Peer-Review 25759793 10.3389/fonc.2015.00049 2234-943X PURPOSE Cutaneous T-cell lymphoma (CTCL) is known to have an excellent response to radiotherapy, an important treatment modality for this disease. In patients with extremity and digit involvement, the irregular surface and depth variations create difficulty in delivering a homogenous dose using electrons. We sought to evaluate photon irradiation with rice packing as tissue equivalence and determine clinical tolerance and response. MATERIALS AND METHODS Three consecutive CTCL patients with extensive lower extremity involvement including the digits were treated using external beam photon therapy with rice packing for tissue compensation. The entire foot was treated to 30-40?Gy in 2-3?Gy per fraction using 6?MV photons prescribed to the mid-plane of an indexed box filled with rice in which the foot was placed. Treatment tolerance and response were monitored with clinical evaluation. RESULTS All patients tolerated the treatment without treatment breaks. Toxicities included grade 3 erythema and desquamation with resolution within 4?weeks. No late toxicities were observed. All patients had a partial response by 4?weeks after therapy with two patients achieving a complete response. Patients reported improved functionality after treatment. No local recurrence has been observed. CONCLUSION Tissue compensation with rice packing offers a convenient, inexpensive, and reproducible method for the treatment of CTCL with highly irregular surfaces. cutaneous T-cell lymphoma|irregular surface|radiotherapy|tissue compensation Links
  • Chaswal,Vibha; Weldon,Michael; Gupta,Nilendu; et al. "Commissioning and comprehensive evaluation of the ArcCHECK cylindrical diode array for VMAT pretreatment delivery QA." JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS. Vol. 15, no. 4. (Jan 2014): 212-225. (Published).Citation Count: 0. Chaswal,Vibha; Weldon,Michael; Gupta,Nilendu; Chakravarti,Arnab; Rong,Yi Commissioning and comprehensive evaluation of the ArcCHECK cylindrical diode array for VMAT pretreatment delivery QA JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS Journal Article Peer-Review 1526-9914 We present commissioning and comprehensive evaluation for ArcCHECK as a QA equipment for volumetric-modulated arc therapy (VMAT), using the 6 MV photon beam with and without the flattening filter, and the SNC patient software (version 6.2). In addition to commissioning involving absolute dose calibration, array calibration, and PMMA density verification, ArcCHECK was evaluated for its response dependency on linac dose rate, instantaneous dose rate, radiation field size, beam angle, and couch insertion. Scatter dose characterization, consistency and symmetry of response, and dosimetry accuracy evaluation for fixed aperture arcs and clinical VMAT patient plans were also investigated. All the evaluation tests were performed with the central plug inserted and the homogeneous PMMA density value. Results of gamma analysis demonstrated an overall agreement between ArcCHECK-measured and TPS-calculated reference doses. The diode based field size dependency was found to be within 0.5% of the reference. The dose rate-based dependency was well within 1% of the TPS reference, and the angular dependency was found to be +/- 3% of the reference, as tested for BEV angles, for both beams. Dosimetry of fixed arcs, using both narrow and wide field widths, resulted in clinically acceptable global gamma passing rates on the 3%/3 mm level and 10% threshold. Dosimetry of narrow arcs showed an improvement over published literature. The clinical VMAT cases demonstrated high level of dosimetry accuracy in gamma passing rates. QUALITY-ASSURANCE|WATER|RADIOTHERAPY|IMRT|DISTRIBUTIONS|QUANTITATIVE-EVALUATION|PHOTON DOSE CALCULATION|DOSIMETRIC VERIFICATION|ANISOTROPIC ANALYTICAL ALGORITHM|MODULATED ARC|quality assurance|angular dependence|Volumetric-modulated arc therapy|ArcCHECK commissioning|ArcCHECK diode array|ArcCHECK evaluation Radiology, Nuclear Medicine & Medical Imaging Web of Science ®
  • Yang,Weilian; Barth,Rolf,F; Huo,Tianyao; et al. "Radiation therapy combined with intracerebral administration of carboplatin for the treatment of brain tumors." RADIATION ONCOLOGY. Vol. 9, (Jan 2014): 25. (Published).Citation Count: 1. Yang,Weilian; Barth,Rolf,F; Huo,Tianyao; Nakkula,Robin,J; Weldon,Michael; Gupta,Nilendu; Agius,Lawrence; Grecula,John,C Radiation therapy combined with intracerebral administration of carboplatin for the treatment of brain tumors RADIATION ONCOLOGY Journal Article Peer-Review 24422671 10.1186/1748-717X-9-25 1748-717X Background: In this study we determined if treatment combining radiation therapy (RT) with intracerebral (i.c.) administration of carboplatin to F98 glioma bearing rats could improve survival over that previously reported by us with a 15 Gy dose (5 Gy x 3) of 6 MV photons. Methods: First, in order to reduce tumor interstitial pressure, a biodistribution study was carried out to determine if pretreatment with dexamethasone alone or in combination with mannitol and furosemide (DMF) would increase carboplatin uptake following convection enhanced delivery (CED). Next, therapy studies were carried out in rats that had received carboplatin either by CED over 30 min (20 mu g) or by Alzet pumps over 7 d (84 mu g), followed by RT using a LINAC to deliver either 20 Gy (5 Gy x 4) or 15 Gy (7.5 Gy x 2) dose at 6 or 24 hrs after drug administration. Finally, a study was carried out to determine if efficacy could be improved by decreasing the time interval between drug administration and RT. Results: Tumor carboplatin values for D and DMF-treated rats were 9.4 +/- 4.4 and 12.4 +/- 3.2 mu g/g, respectively, which were not significantly different (P = 0.14). The best survival data were obtained by combining pump delivery with 5 Gy x 4 of X-irradiation with a mean survival time (MST) of 107.7 d and a 43% cure rate vs. 83.6 d with CED vs. 30-35 d for RT alone and 24.6 d for untreated controls. Treatment-related mortality was observed when RT was initiated 6 h after CED of carboplatin and RT was started 7 d after tumor implantation. Dividing carboplatin into two 10 mu g doses and RT into two 7.5 Gy fractions, administered 24 hrs later, yielded survival data (MST 82.1 d with a 25% cure rate) equivalent to that previously reported with 5 Gy x 3 and 20 mu g of carboplatin. Conclusions: Although the best survival data were obtained by pump delivery, CED was highly effective in combination with 20 Gy, or as previously reported, 15 Gy, and the latter would be preferable since it would produce less late tissue effects. COMBINATION|SYNCHROTRON X-RAYS|NEUTRON-CAPTURE THERAPY|GLIOBLASTOMA|CONVECTION-ENHANCED DELIVERY|RADIOTHERAPY|ADJUVANT TEMOZOLOMIDE|CONCOMITANT|GLIOMA-BEARING RATS|PHOTON IRRADIATION|BRAIN TUMORS|carboplatin|radiotherapy|F98 glioma|convection enhanced delivery Oncology|Radiology, Nuclear Medicine & Medical Imaging Links
  • Lu,Lanchun; Bondra,Kathryn; Gupta,Nilendu; et al. "Using NanoDot dosimetry to study the RS 2000 X-ray Biological Irradiator." International journal of radiation biology. Vol. 89, no. 12. (Dec 2013): 1094-1099. (Published).Citation Count: 1. Lu,Lanchun; Bondra,Kathryn; Gupta,Nilendu; Sommerfeld,James; Chronowski,Christopher; Leasure,Justin; Singh,Mamata; Pelloski,Christopher,E Using NanoDot dosimetry to study the RS 2000 X-ray Biological Irradiator. International journal of radiation biology Journal Article Peer-Review 23786571 10.3109/09553002.2013.817703 0955-3002 Purpose: To use NanoDot dosimeters to study the RS 2000 X-ray Biological Irradiator dosimetry characteristics and perform in vivo dosimetry for cell or small animal experiments. Methods and materials: We first calibrated the Landauer NanoDot (TM) Reader by irradiating some NanoDot dosimeters with a set of known doses at specific positions defined by the irradiator. A group of five NanoDot dosimeters were placed at five specific positions where the dose rates were known and provided by the irradiator. Each group was irradiated for a set of times respectively. By correlating the readings of dosimeters with the given irradiated doses, we established the dose-reading relationship for the irradiator under the specific running condition. The established calibration curve was validated by exposing arbitrary known doses to a set of dosimeters, using the Landauer NanoDot (TM) Reader to measure the doses, and then making the comparison between the two doses. To study the dose gradient of the X-ray inside the irradiated target (dose variation/cm), we placed dosimeters under different thicknesses of water-equivalent bolus and irradiated them, then measured the doses to determine the dose gradient. Results: Using the method described above, we were able to calibrate the Landauer InLight NanoDot (TM) Reader and use NanoDot dosimeters to measure the actual doses delivered to the targets for the cell/small animal experiments that use the RS 2000 X-ray Biological Irradiator. Conclusions: NanoDots are ideal dosimeters to use for in vivo dosimetry for cell/small animal irradiation experiments. The dose decrease inside the animal tissue is about 20% per cm. PROTOCOL|BEAM DOSIMETRY|AAPM TG-61 REPORT|calibration|dose gradient|cell/small animal experiments|NanoDot dosimeter|RS 2000 X-ray Biological Irradiator Biology|Nuclear Science & Technology|Radiology, Nuclear Medicine & Medical Imaging Links
  • McGregor,John; Grecula,John; Ammirati,Mario; et al. "LONG TERM FOLLOW-UP AFTER STEREOTACTIC RADIOSURGERY FOR THE TREATMENT OF MENINGIOMAS." NEURO-ONCOLOGY. Vol. 15, (Nov 2013): 184-184. (Published).Citation Count: 0. McGregor,John; Grecula,John; Ammirati,Mario; Pelloski,Christopher; Lu,Lanchun; Gupta,Nilendu; Bell,Susan LONG TERM FOLLOW-UP AFTER STEREOTACTIC RADIOSURGERY FOR THE TREATMENT OF MENINGIOMAS NEURO-ONCOLOGY Other Peer-Review 1522-8517 Oncology|Clinical Neurology Web of Science ®

Most Recent Conference Papers & Proceedings

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  • McGregor,John; Grecula,John; Ammirati,Mario; Pelloski,Christopher; Lu,Lanchun; Gupta,Nilendu; Bell,Susan. "LONG TERM FOLLOW-UP AFTER STEREOTACTIC RADIOSURGERY FOR THE TREATMENT OF MENINGIOMAS." In: NEURO-ONCOLOGY. Vol. 15. 184-184. Editor-Review] (Published). McGregor,John; Grecula,John; Ammirati,Mario; Pelloski,Christopher; Lu,Lanchun; Gupta,Nilendu; Bell,Susan LONG TERM FOLLOW-UP AFTER STEREOTACTIC RADIOSURGERY FOR THE TREATMENT OF MENINGIOMAS 4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO) Editor-Review 1 NEURO-ONCOLOGY 1522-8517 Oncology|Clinical Neurology Web of Science ®
  • Majithia,L; Hattie,T; Weldon,M; Boyle,D; Gupta,N; Sommerfeld,J; Porcu,P; Wong,H; Siddiqui,F; Welliver,M,X. "Novel Tissue Compensation With Photon Irradiation for Cutaneous T-Cell Lymphoma With Irregular Surfaces." In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. Vol. 87. S684-S684. Peer-Review] (Published). Majithia,L; Hattie,T; Weldon,M; Boyle,D; Gupta,N; Sommerfeld,J; Porcu,P; Wong,H; Siddiqui,F; Welliver,M,X Novel Tissue Compensation With Photon Irradiation for Cutaneous T-Cell Lymphoma With Irregular Surfaces 55th Annual Meetings of the American-Society-for-Radiation-Oncology (ASTRO) Peer-Review 1 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 0360-3016 Oncology|Radiology, Nuclear Medicine & Medical Imaging Web of Science ®
  • FILIPPI,J; Patel,A; Gupta,N; Weldon,M; Woollard,J; Ayan,A; Rong,Y; Martin,D; Pelloski,C; Welliver,M; Lu,L. "A Clinical Dosimetry Analysis of Total Body Irradiation for Leukemia Patients." In: MEDICAL PHYSICS. Vol. 40. 254. Peer-Review] (Published). FILIPPI,J; Patel,A; Gupta,N; Weldon,M; Woollard,J; Ayan,A; Rong,Y; Martin,D; Pelloski,C; Welliver,M; Lu,L A Clinical Dosimetry Analysis of Total Body Irradiation for Leukemia Patients 55th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM) Peer-Review 1 MEDICAL PHYSICS 0094-2405 10.1118/1.4814651 Radiology, Nuclear Medicine & Medical Imaging Links
  • Lu,L; Bondra,K; Gupta,N; Sommerfeld,J; Pelloski,C,E. "NanoDots Dosimetry for RS 2000 X-Ray Biological Irradiator." In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. Vol. 84. S856-S856. Peer-Review] (Published). Lu,L; Bondra,K; Gupta,N; Sommerfeld,J; Pelloski,C,E NanoDots Dosimetry for RS 2000 X-Ray Biological Irradiator 54th Annual Scientific Meeting of the American-Society-for-Radiation-Oncology (ASTRO) Peer-Review 1 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 0360-3016 Oncology|Radiology, Nuclear Medicine & Medical Imaging Web of Science ®
  • Rong,Y; Gupta,N; Kuhn,K; Glass,P; Fullenkamp,M; Quick,A. "Respiratory-gated Deep-inspiration Breath Hold Left Breast Irradiation Incorporating Real-time 3D Surface Optical Tracking and Integrated MV Cine Acquisition." In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. Vol. 84. S215-S216. Peer-Review] (Published). Rong,Y; Gupta,N; Kuhn,K; Glass,P; Fullenkamp,M; Quick,A Respiratory-gated Deep-inspiration Breath Hold Left Breast Irradiation Incorporating Real-time 3D Surface Optical Tracking and Integrated MV Cine Acquisition 54th Annual Scientific Meeting of the American-Society-for-Radiation-Oncology (ASTRO) Peer-Review 1 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 0360-3016 Oncology|Radiology, Nuclear Medicine & Medical Imaging Web of Science ®

Most Recent Scholarly Presentations

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  • Dr. Nilendu Gupta, Lecturer. "A Study On the Use of Full-Field Non-Flat Beams for IMRT Treatment." (Jan 2008) Dr. Nilendu Gupta A Study On the Use of Full-Field Non-Flat Beams for IMRT Treatment Lecturer National
  • Dr. Nilendu Gupta, Lecturer. "Development of Megavoltage Cone Beam Image Guided Radiation Therapy (IGRT) for Mini-Multileaf Collimator (mMLC) Based IMRT and Radiosurgery Applications." (Jan 2008) Dr. Nilendu Gupta Development of Megavoltage Cone Beam Image Guided Radiation Therapy (IGRT) for Mini-Multileaf Collimator (mMLC) Based IMRT and Radiosurgery Applications Lecturer National
  • Dr. Nilendu Gupta, Lecturer. "A QA Device to Perform End-To-End Spatial Accuracy Tests of Target Irradiation in Stereotactic Radiosurgery." (Jan 2006) Dr. Nilendu Gupta A QA Device to Perform End-To-End Spatial Accuracy Tests of Target Irradiation in Stereotactic Radiosurgery Lecturer National
  • Dr. Nilendu Gupta, Seminar Presenter. "Introduction to Radiation Oncology and Overview of the OSU Nodal Atlas Project." (Jan 2006) Dr. Nilendu Gupta Introduction to Radiation Oncology and Overview of the OSU Nodal Atlas Project Seminar Presenter Local
  • Dr. Nilendu Gupta, Lecturer. "A Study of the Effects of Seed Migration On Prostate Post-Seed Dose Plan Evaluation." (Jan 2005) Dr. Nilendu Gupta A Study of the Effects of Seed Migration On Prostate Post-Seed Dose Plan Evaluation Lecturer National