Photo of Andrew S. Bowman

Andrew S. Bowman

  • Assistant Professor, Veterinary Preventive Medicine
    The Ohio State University
  • bowman.214@osu.edu
  • 1920 Coffey Road
    Columbus, Ohio 43210
  • Phone: (614) 292-6923
    Fax: (614) 292-4142
  • Most Common Publication Keywords # of Pubs
  • UNITED-STATES3
  • AMERICAN PIGS2
  • GENETIC EVOLUTION2
  • TRANSMISSION2
  • A VIRUSES1
  • ANTIBODY-RESPONSES1
  • ANTIGENIC CARTOGRAPHY1
  • ANTIGENIC DRIFT1
  • ANTIGENIC VARIANT1
  • CARTOGRAPHY1
  • Most Common Publication Subject Categories # of Pubs
  • VIROLOGY2
  • FOOD SCIENCE & TECHNOLOGY1

Most Recent Journal Articles

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  • Feng Z, Baroch JA, Long LP, Xu Y, Cunningham FL, Pedersen K, Lutman MW, Schmit BS, Bowman AS, DeLiberto TJ, Wan XF. "Infections of H3 subtypes of influenza A viruses in feral swine in the United States." Emerging Infectious Diseases. Vol. 20, no. 5. (May 2014): ?. (Published). Feng Z, Baroch JA, Long LP, Xu Y, Cunningham FL, Pedersen K, Lutman MW, Schmit BS, Bowman AS, DeLiberto TJ, Wan XF Infections of H3 subtypes of influenza A viruses in feral swine in the United States Emerging Infectious Diseases Journal Article Peer-Review Acquisition of data and manuscript preparation.
  • Fries AC, Nolting JM, Bowman AS, Killian ML, Wentworth DE, Slemons RD. "Genomic analyses detect Eurasian-lineage H10 and additional H14 influenza A viruses recovered from waterfowl in the central United States." Influenza and Other Respiratory Viruses. Vol. Early View, (Apr 2014): on-line. (Published). Fries AC, Nolting JM, Bowman AS, Killian ML, Wentworth DE, Slemons RD Genomic analyses detect Eurasian-lineage H10 and additional H14 influenza A viruses recovered from waterfowl in the central United States Influenza and Other Respiratory Viruses Journal Article Peer-Review Conception and design of the work, analysis and interpretation of data, and manuscript preparation. 10.1111/irv.12250 1750-2659 DOI
  • Bowman AS, Workman JD, Nolting JM, Nelson SW, Slemons RD. "Exploration of risk factors contributing to the presence of influenza A virus in swine at agricultural." Emerging Microbes & Infections. Vol. 3, (Jan 2014): e5. (Published). Bowman AS, Workman JD, Nolting JM, Nelson SW, Slemons RD Exploration of risk factors contributing to the presence of influenza A virus in swine at agricultural Emerging Microbes & Infections Journal Article Peer-Review Conception and design of the work, acquisition of data, analysis and interpretation of data, and manuscript preparation doi:10.1038/emi.2014.5 2222-1751 DOI
  • Ye J, Xu Y, Harris J, Sun H, Bowman AS, Cunningham F, Cardona C, Yoon KJ, Slemons RD, Wan XF. "Mutation from arginine to lysine at the position 189 of hemagglutinin contributes to the antigenic drift in H3N2 swine influenza viruses." Virology. Vol. 446, no. 1-2. (Nov 2013): 225-229. (Published).Citation Count: 0. Ye J, Xu Y, Harris J, Sun H, Bowman AS, Cunningham F, Cardona C, Yoon KJ, Slemons RD, Wan XF Mutation from arginine to lysine at the position 189 of hemagglutinin contributes to the antigenic drift in H3N2 swine influenza viruses. Virology Journal Article Peer-Review Acquisition of data, interpretation of data, and manuscript preparation 24074585 10.1016/j.virol.2013.08.004 0042-6822 Two distinct antigenic clusters were previously identified among the H3N2 swine influenza A viruses (IAVs) and were designated H3N2SIV-alpha and H3N2SIV-beta (Feng et al., 2013. Journal of Virology 87 (13), 7655-7667). A consistent mutation was observed at the position 189 of hemagglutinin (R189K) between H3N2SIV-alpha and H3N2SIV-beta fair isolates. To evaluate the contribution of R189K mutation to the antigenic drift from H3N2SIV-alpha to H3N2SIV-beta, four reassortant viruses with 189R or 189K were generated. The antigenic cartography demonstrated that the R189K mutation in the hemagglutinin of H3N2 IAV contributed to the antigenic drift, separating these viruses into H3N2SIV-alpha to H3N2SIV-beta. This R189K mutation was also found to contribute to the cross-reaction with several ferret sera raised against historical human IAVs with hemagglutinin carrying 189K. This study suggests that the R189K mutation plays a vital role in the antigenicity of swine and human H3N2 IAVs and identification of this antigenic determinant will help us rapidly identify antigenic variants in influenza surveillance. (C) 2013 Elsevier Inc. All rights reserved. A VIRUSES|TRANSMISSION|UNITED-STATES|DOGS|AMERICAN PIGS|EQUINE INFLUENZA|GENETIC EVOLUTION|CARTOGRAPHY|antigenic variant|influenza A virus|H3N2|serological assay|antigenic cartography|antigenic drift|H3N2v|R189K Virology Links
  • Feng Z,Gomez J, Bowman AS, Ye J, Long LP, Nelson S, Yang J, Martin B , Jia K, Nolting JM, Cunningham F, Cardona C, Zhang J, Yoon KJ, Slemons RD, Wan XF. "Antigenic characterization of H3N2 influenza A viruses from Ohio agricultural fairs." Journal of Virology. Vol. 87, no. 13. (Jul 2013): 7655-7667. (Published).Citation Count: 1. Feng Z,Gomez J, Bowman AS, Ye J, Long LP, Nelson S, Yang J, Martin B , Jia K, Nolting JM, Cunningham F, Cardona C, Zhang J, Yoon KJ, Slemons RD, Wan XF Antigenic characterization of H3N2 influenza A viruses from Ohio agricultural fairs Journal of Virology Journal Article Peer-Review Design of the work, interpretation of data, and manuscript preparation 23637412 10.1128/JVI.00804-13 0022-538X The demonstrated link between the emergence of H3N2 variant (H3N2v) influenza A viruses (IAVs) and swine exposure at agricultural fairs has raised concerns about the human health risk posed by IAV-infected swine. Understanding the antigenic profiles of IAVs circulating in pigs at agricultural fairs is critical to developing effective prevention and control strategies. Here, 68 H3N2 IAV isolates recovered from pigs at Ohio fairs (2009 to 2011) were antigenically characterized. These isolates were compared with other H3 IAVs recovered from commercial swine, wild birds, and canines, along with human seasonal and variant H3N2 IAVs. Antigenic cartography demonstrated that H3N2 IAV isolates from Ohio fairs could be divided into two antigenic groups: (i) the 2009 fair isolates and (ii) the 2010 and 2011 fair isolates. These same two antigenic clusters have also been observed in commercial swine populations in recent years. Human H3N2v isolates from 2010 and 2011 are antigenically clustered with swine-origin IAVs from the same time period. The isolates recovered from pigs at fairs did not cross-react with ferret antisera produced against the human seasonal H3N2 IAVs circulating during the past decade, raising the question of the degree of immunity that the human population has to swine-origin H3N2 IAVs. Our results demonstrate that H3N2 IAVs infecting pigs at fairs and H3N2v isolates were antigenically similar to the IAVs circulating in commercial swine, demonstrating that exhibition swine can function as a bridge between commercial swine and the human population. HIGH-THROUGHPUT|INFECTION|HUMANS|SWINE INFLUENZA|HEMAGGLUTININ|TRANSMISSION|UNITED-STATES|ANTIBODY-RESPONSES|AMERICAN PIGS|GENETIC EVOLUTION Virology Links

Most Recent Conference Papers & Proceedings

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  • Szablewski C, Nelson SW, Nolting JM, Bowman AS. "Comparative evaluation of snout wipes for use in influenza A virus surveillance." In: Proceedings of 45th Meeting of the American Association of Swine Veterinarians. Dallas: American Association of Swine Veterinarians. 367-368. Peer-Review] (Published). Szablewski C, Nelson SW, Nolting JM, Bowman AS Comparative evaluation of snout wipes for use in influenza A virus surveillance Conference Proceeding 45th Meeting of the American Association of Swine Veterinarians Peer-Review 3 Conference Proceedings American Association of Swine Veterinarians
  • Bowman A, Stucker K, Schobel S, Wentworth D, Cardona C, Sreevatsan S, Wan X-F, Slemons R. "Molecular epidemiology of influenza A virus infections in swine at agricultural fairs in the United States of America." In: Proceedings of Options for the Control of Influenza VIII. Cape Town: Options for the Control of Influenza VIII. 667/LBA-P2-057. Peer-Review] (Published). Bowman A, Stucker K, Schobel S, Wentworth D, Cardona C, Sreevatsan S, Wan X-F, Slemons R Molecular epidemiology of influenza A virus infections in swine at agricultural fairs in the United States of America Conference Proceeding Options for the Control of Influenza VIII Peer-Review 3 Conference Proceedings International Society for Influenza and other Respiratory Virus Diseases Options for the Control of Influenza VIII
  • Ye J, Xu Y, Harris J, Bowman A, Cunningham F, Cardona C, Yoon K, Slemons R, Wan X-F. "Mutation from arginine to lysine at the position 189 of hemagglutinin contributes to the antigenic drift in H3N2 swine influenza viruses." In: Proceedings of Options for the Control of Influenza VIII. Cape Town: Options for the Control of Influenza VIII. 510/P2-600. Peer-Review] (Published). Ye J, Xu Y, Harris J, Bowman A, Cunningham F, Cardona C, Yoon K, Slemons R, Wan X-F Mutation from arginine to lysine at the position 189 of hemagglutinin contributes to the antigenic drift in H3N2 swine influenza viruses Conference Proceeding Options for the Control of Influenza VIII Peer-Review 3 Conference Proceedings International Society for Influenza and other Respiratory Virus Diseases Options for the Control of Influenza VIII
  • Garten R, Balish A, Killian ML, Swenson S, Bowman A, Davis C, Davis W, Shu B, Berman L, Barnes J, Lindstrom S, Villanueva J, Klimov A. "Characterization of Influenza A(H3N2)v at County and State Agricultural Fairs in the U.S." Granada: 15th International Negative Strand Virus Meeting. 336. Peer-Review] (Published). Garten R, Balish A, Killian ML, Swenson S, Bowman A, Davis C, Davis W, Shu B, Berman L, Barnes J, Lindstrom S, Villanueva J, Klimov A Characterization of Influenza A(H3N2)v at County and State Agricultural Fairs in the U.S. Conference Proceeding Peer-Review 3 Conference Proceedings 15th International Negative Strand Virus Meeting
  • Swenson S, Landgraf J, Killian ML, Shu B, Lindstrom S, Yu X, Klimov A, Vincent A, Zhang Y, Bowman, A. "Swine Influenza Virus Infection of Pigs and People at a County Fair." Durban: International Pig Veterinary Society Congress. P01.018. (Published). Swenson S, Landgraf J, Killian ML, Shu B, Lindstrom S, Yu X, Klimov A, Vincent A, Zhang Y, Bowman, A Swine Influenza Virus Infection of Pigs and People at a County Fair Conference Proceeding 2 Conference Proceedings International Pig Veterinary Society Congress

Most Recent Scholarly Presentations

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  • Bowman AS, Poster Presenter. "Molecular epidemiology of influenza A virus infections in swine at agricultural fairs." Presented at 45th Meeting of the American Association of Swine Veterinarians, Peers within Field., Dallas, Texas, United States. (Mar 2014) Bowman AS Molecular epidemiology of influenza A virus infections in swine at agricultural fairs Poster Presenter 1 45th Meeting of the American Association of Swine Veterinarians International
  • Bowman AS, Presenter. "Swine Influenza A Infection in Exhibition Swine." Presented at 130th Annual Meeting of the Indiana Veterinary Medical Association, Peers within Field., Indianapolis, Indiana, United States. (Feb 2014) Bowman AS Swine Influenza A Infection in Exhibition Swine Presenter 130th Annual Meeting of the Indiana Veterinary Medical Association Local
  • A. Bowman, Presenter. "Investigating influenza A virus infections occurring at agricultural fairs: a unique swine-human interface." Presented at Ohio State University RNA Virus Seminar Series, Columbus, Ohio, United States. (Jan 2014) A. Bowman Investigating influenza A virus infections occurring at agricultural fairs: a unique swine-human interface Presenter Ohio State University RNA Virus Seminar Series Local
  • Bowman AS, Presenter. "The Next Chapter: Influenza A Virus Swine Surveillance at Agricultural Fairs During 2013." Presented at NIAID Centers of Excellence for Influenza Research and Surveillance Lecture Series, Peers within Field., Webinar (Dec 2013) Bowman AS The Next Chapter: Influenza A Virus Swine Surveillance at Agricultural Fairs During 2013 Presenter NIAID Centers of Excellence for Influenza Research and Surveillance Lecture Series International
  • Bowman AS, Presenter. "Recent Findings from Influenza A Virus Surveillance in Swine at Agricultural Fairs." Presented at United States Animal Health Association, Government Officials., San Diego, California, United States. (Oct 2013) Bowman AS Recent Findings from Influenza A Virus Surveillance in Swine at Agricultural Fairs Presenter United States Animal Health Association Transmissible Diseases of Swine National