Photo of Andrew S. Bowman

Andrew S. Bowman

  • Assistant Professor, Veterinary Preventive Medicine
    The Ohio State University
  • bowman.214@osu.edu
  • 1920 Coffey Road
    Columbus, Ohio 43210
  • Phone: (614) 292-6923
    Fax: (614) 292-4142
  • Most Common Publication Keywords # of Pubs
  • UNITED-STATES3
  • COUNTY FAIR2
  • INFLUENZA A VIRUS2
  • PIGS2
  • SURVEILLANCE2
  • SWINE2
  • A VIRUSES1
  • AGRICULTURAL FAIR1
  • ANIMAL INFLUENZA1
  • AVIAN INFLUENZA1
  • Most Common Publication Subject Categories # of Pubs
  • INFECTIOUS DISEASES3
  • VIROLOGY2
  • IMMUNOLOGY1
  • VETERINARY SCIENCES1

Most Recent Journal Articles

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  • Fries AC, Nolting JM, Bowman AS, Lin X, Halpin RA, Wester E, FedorovaN, StockwellTB, Das SR, Dugan VG, Wentworth DE, G HL, Slemons RD. "Spread and persistence of influenza a viruses in waterfowl hosts in the north american Mississippi migratory flyway." Journal of Virology. Vol. 89, no. 10. (May 2015): 5371-5381. (Published). Fries AC, Nolting JM, Bowman AS, Lin X, Halpin RA, Wester E, FedorovaN, StockwellTB, Das SR, Dugan VG, Wentworth DE, G HL, Slemons RD Spread and persistence of influenza a viruses in waterfowl hosts in the north american Mississippi migratory flyway. Journal of Virology Journal Article Peer-Review Interpretation of the data and manuscript preparation. 25741003 10.1128/JVI.03249-14 0022-538X UNLABELLED While geographic distance often restricts the spread of pathogens via hosts, this barrier may be compromised when host species are mobile. Migratory waterfowl in the order Anseriformes are important reservoir hosts for diverse populations of avian-origin influenza A viruses (AIVs) and are assumed to spread AIVs during their annual continental-scale migrations. However, support for this hypothesis is limited, and it is rarely tested using data from comprehensive surveillance efforts incorporating both the temporal and spatial aspects of host migratory patterns. We conducted intensive AIV surveillance of waterfowl using the North American Mississippi Migratory Flyway (MMF) over three autumn migratory seasons. Viral isolates (n = 297) from multiple host species were sequenced and analyzed for patterns of gene dispersal between northern staging and southern wintering locations. Using a phylogenetic and nucleotide identity framework, we observed a larger amount of gene dispersal within this flyway rather than between the other three longitudinally identified North American flyways. Across seasons, we observed patterns of regional persistence of diversity for each genomic segment, along with limited survival of dispersed AIV gene lineages. Reassortment increased with both time and distance, resulting in transient AIV constellations. This study shows that within the MMF, AIV gene flow favors spread along the migratory corridor within a season, and also that intensive surveillance during bird migration is important for identifying virus dispersal on time scales relevant to pandemic responsiveness. In addition, this study indicates that comprehensive monitoring programs to capture AIV diversity are critical for providing insight into AIV evolution and ecology in a major natural reservoir. IMPORTANCE Migratory birds are a reservoir for antigenic and genetic diversity of influenza A viruses (AIVs) and are implicated in the spread of virus diversity that has contributed to previous pandemic events. Evidence for dispersal of avian-origin AIVs by migratory birds is rarely examined on temporal scales relevant to pandemic or panzootic threats. Therefore, characterizing AIV movement by hosts within a migratory season is important for implementing effective surveillance strategies. We conducted surveillance following birds along a major North American migratory route and observed that within a migratory season, AIVs rapidly reassorted and gene lineages were dispersed primarily within the migratory corridor. Patterns of regional persistence were observed across seasons for each gene segment. We show that dispersal of AIV gene lineages by migratory birds occurs quickly along migratory routes and that surveillance for AIVs threatening human and animal health should focus attention on these routes. Links
  • Bowman AS, Nolting JM, Workman JD, Cooper M, Fisher AE, Marsh BM, Forshey T. "The inability to screen exhibition swine for influenza A virus using body temperature." Zoonoses and Public Health. Vol. Epub ahead of print, (Apr 2015): ZPH12201. (Published). Bowman AS, Nolting JM, Workman JD, Cooper M, Fisher AE, Marsh BM, Forshey T. The inability to screen exhibition swine for influenza A virus using body temperature Zoonoses and Public Health Journal Article Peer-Review Conception and design of the work, acquisition of data, analysis and interpretation of data, and manuscript preparation. 10.1111/zph.12201 DOI
  • Bowman AS, Krogwold RA, Price T, Davis M, Moeller SJ. "Investigating the introduction of porcine epidemic diarrhea virus into an Ohio swine operation." BMC Veterinary Research. Vol. 11, (Feb 2015): 38. (Published).Citation Count: 0. Bowman AS, Krogwold RA, Price T, Davis M, Moeller SJ Investigating the introduction of porcine epidemic diarrhea virus into an Ohio swine operation BMC Veterinary Research Journal Article Peer-Review Design of the work, acquisition of data, analysis and interpretation of data, and manuscript preparation. 25779795 10.1186/s12917-015-0348-2 1746-6148 Background: Porcine Epidemic Diarrhea virus (PEDV) is a highly transmissible coronavirus that causes a severe enteric disease that is particularly deadly for neonatal piglets. Since its introduction to the United States in 2013, PEDV has spread quickly across the country and has caused significant financial losses to pork producers. With no fully licensed vaccines currently available in the United States, prevention and control of PEDV disease is heavily reliant on biosecurity measures. Despite proven, effective biosecurity practices, multiple sites and production stages, within and across designated production flows in an Ohio swine operation broke with confirmed PEDV in January 2014, leading the producer and attending veterinarian to investigate the route of introduction. Case presentation: On January 12, 2014, several sows within a production flow were noted with signs of enteric illness. Within a few days, illness had spread to most of the sows in the facility and was confirmed by RT-PCR to be PEDV. Within a short time period, confirmed disease was present on multiple sites within and across breeding and post weaning production flows of the operation and mortality approached 100% in neonatal piglets. After an epidemiologic investigation, an outsourced, pelleted piglet diet was identified for assessment, and a bioassay, where naive piglets were fed the suspected feed pellets, was initiated to test the pellets for infectious PEDV. Conclusions: The epidemiological investigation provided strong evidence for contaminated feed as the source of the outbreak. In addition, feed pellets collected from unopened bags at the affected sites tested positive for PEDV using RT-PCR. However, the bioassay study was not able to show infectivity when feeding the suspected feed pellets to a small number of naive piglets. The results highlight the critical need for surveillance of feed and feed components to further define transmission avenues in an effort to limit the spread of PEDV throughout the U.S. swine industry. INFECTION|UNITED-STATES|FEED|PEDV|feed|swine Veterinary Sciences Links
  • Bowman AS, Nelson SW, Page SL, Nolting JM, Killian ML, Sreevatsan S, Slemons RD. "Swine-to-Human Transmission of Influenza A(H3N2) Virus at Agricultural Fairs, Ohio, USA, 2012." Emerging Infectious Diseases. Vol. 20, no. 9. (Sep 2014): 1472-1480. (Published).Citation Count: 1. Bowman AS, Nelson SW, Page SL, Nolting JM, Killian ML, Sreevatsan S, Slemons RD Swine-to-Human Transmission of Influenza A(H3N2) Virus at Agricultural Fairs, Ohio, USA, 2012. Emerging Infectious Diseases Journal Article Peer-Review Conception and design of the work, acquisition of data, analysis and interpretation of data, and manuscript preparation 25148572 10.3201/eid2009.131082 1080-6040 Agricultural fairs provide an opportunity for bidirectional transmission of influenza A viruses. We sought to determine influenza A virus activity among swine at fairs in the United States. As part of an ongoing active influenza A virus surveillance project, nasal swab samples were collected from exhibition swine at 40 selected Ohio agricultural fairs during 2012. Influenza A(H3N2) virus was isolated from swine at 10 of the fairs. According to a concurrent public health investigation, 7 of the 10 fairs were epidemiologically linked to confirmed human infections with influenza A(H3N2) variant virus. Comparison of genome sequences of the subtype H3N2 isolates recovered from humans and swine from each fair revealed nucleotide identities of >99.7%, confirming zoonotic transmission between swine and humans. All influenza A(H3N2) viruses isolated in this study, regardless of host species or fair, were >99.5% identical, indicating that 1 virus strain was widely circulating among exhibition swine in Ohio during 2012. HUMAN INFECTIONS|A VIRUSES|H3N2 VIRUS|PIGS|MAXIMUM-LIKELIHOOD|ORIGIN|UNITED-STATES|ANIMAL INFLUENZA|VARIANT VIRUS|COUNTY FAIR Immunology|Infectious Diseases Links
  • Edwards JL, Nelson SW,Workman JD, Slemons RD, Szablewski CM, Nolting JM, Bowman AS. "Utility of snout wipe samples for influenza A virus surveillance in exhibition swine populations." Influenza and Other Respiratory Viruses. Vol. 8, no. 5. (Sep 2014): 574-579. (Published).Citation Count: 0. Edwards JL, Nelson SW,Workman JD, Slemons RD, Szablewski CM, Nolting JM, Bowman AS Utility of snout wipe samples for influenza A virus surveillance in exhibition swine populations Influenza and Other Respiratory Viruses Journal Article Peer-Review Conception and design of the work, acquisition of data, analysis and interpretation of data, and manuscript preparation. 25043408 10.1111/irv.12270 1750-2640 BackgroundSporadic influenza A virus (IAV) outbreaks in humans and swine have resulted from commingling of large numbers of people and pigs at agricultural fairs in the United States. Current antemortem IAV surveillance strategies in swine require collecting nasal swabs, which entails restraining pigs with snares. Restraint is labor-intensive for samplers, stressful for pigs, and displeasing to onlookers because pigs often resist and vocalize. ObjectiveTo evaluate the utility of snout wipes in exhibition swine as a method to make IAV surveillance efforts less intrusive, less labor-intensive, and more widely accepted among pig owners and exhibition officials. MethodsThree materials (rayon/polyester gauze, cotton gauze, and Swiffer((R)) Sweeper dry cloths) were inoculated with IAV, and viral recoveries from these materials were quantified using qRT-PCR and TCID50 assays. In a field trial, paired cotton gauze snout wipes and gold standard polyester-tipped nasal swabs were collected from 553 pigs representing 29 agricultural fairs and the qualitative results of rRT-PCR and viral isolation were compared. Results and ConclusionsViral recoveries from potential snout wipe materials ranged from 026 to 159 log(10) TCID50/ml less than that of the positive control in which no substrate was included; rayon/polyester gauze performed significantly worse than the other materials. In the field, snout wipes and nasal swabs had high levels of agreement for both rRT-PCR detection and virus isolation. Although further investigation and refinement of the sampling method is needed, results indicate that snout wipes will facilitate convenient and undisruptive IAV surveillance in pigs at agricultural fairs. OUTBREAK|INFECTIONS|PIGS|RESPIRATORY-SYNDROME-VIRUS|TRANSMISSION|UNITED-STATES|ORAL-FLUID SAMPLES|COUNTY FAIR|AGRICULTURAL FAIR|SWAB MATERIALS|surveillance|influenza A virus|zoonotic disease|diagnostic techniques and procedures|swine Infectious Diseases|Virology Links

Most Recent Conference Papers & Proceedings

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  • Bliss N, Nolting JM, Nelson SW, Bowman AS. "Determining the frequency and associated risk factors of influenza A virus infections in swine upon arrival at agriculture exhbtions." In: Proceedings of 46th Meeting of the American Association of Swine Veterinarians. Orlando: American Association of Swine Veterinarians. 355-356. (Published). Bliss N, Nolting JM, Nelson SW, Bowman AS Determining the frequency and associated risk factors of influenza A virus infections in swine upon arrival at agriculture exhbtions Conference Proceeding 46th Meeting of the American Association of Swine Veterinarians 3 Conference Proceedings American Association of Swine Veterinarians
  • Edmunson AM, Nolting JM, Nelson SW, Bowman AS. "Examining spatial dynamics of influenza A virus in swine at agricultural fairs." In: Proceedings of 46th Meeting of the American Association of Swine Veterinarians. Orlando: American Association of Swine Veterinarians. 307-308. (Published). Edmunson AM, Nolting JM, Nelson SW, Bowman AS Examining spatial dynamics of influenza A virus in swine at agricultural fairs Conference Proceeding 46th Meeting of the American Association of Swine Veterinarians 3 Conference Proceedings American Association of Swine Veterinarians
  • Szablewski CM, Bowman AS. "Influenza A virus testing: Which sample material should you use?." In: Proceedings of 46th Meeting of the American Association of Swine Veterinarians. Orlando: American Association of Swine Veterinarians. 347-348. (Published). Szablewski CM, Bowman AS Influenza A virus testing: Which sample material should you use? Conference Proceeding 46th Meeting of the American Association of Swine Veterinarians 3 Conference Proceedings American Association of Swine Veterinarians
  • Gerken E, Nolting JM, Bowman AS, Slemons RD. "Comparison of Real-Time Reverse Transcription-PCR and Virus Isolation with Embryonated Chicken Eggs for the Detection of Influenza A Virus from Wild Waterfowl." In: Proceedings of 2014 Annual Meeting. Denver: American Association of Avian Pathologists Symposium & Scientific Program. 65. (Published). Gerken E, Nolting JM, Bowman AS, Slemons RD Comparison of Real-Time Reverse Transcription-PCR and Virus Isolation with Embryonated Chicken Eggs for the Detection of Influenza A Virus from Wild Waterfowl Conference Proceeding 2014 Annual Meeting 3 Conference Proceedings American Association of Avian Pathologists Symposium & Scientific Program
  • Nolting JM, Bowman AS, Fries AC, Killian ML, Slemons RD. "Challenges with the Detection and Characterization of Avian-Origin Influenza A Viruses from Wild-Waterfowl." St. Paul: North Central Avian Disease Conference. 6. (Published). Nolting JM, Bowman AS, Fries AC, Killian ML, Slemons RD Challenges with the Detection and Characterization of Avian-Origin Influenza A Viruses from Wild-Waterfowl Conference Proceeding 3 Conference Proceedings North Central Avian Disease Conference

Most Recent Scholarly Presentations

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  • Bowman AS, Presenter. "Examining influenza A virus activity in swine at agricultural fairs in the United States." Presented at 3rd International Symposium on Neglected Influenza Viruses, Athens, Georgia, United States. (Apr 2015) Bowman AS Examining influenza A virus activity in swine at agricultural fairs in the United States Presenter 3rd International Symposium on Neglected Influenza Viruses International
  • Bowman AS, Poster Presenter. "Influenza A viurs surveillance in waterfowl in Missouri, USA, 2015-2013." Presented at 9th International Symposium on Avian Influenza, Athens, Georgia, United States. (Apr 2015) Bowman AS Influenza A viurs surveillance in waterfowl in Missouri, USA, 2015-2013 Poster Presenter 9th International Symposium on Avian Influenza International
  • Bowman AS, Presenter. "Frequent movement of US exhibition swine impacts influenza A virus dynamics." Presented at NIAID Centers of Excellence for Influenza Research and Surveillance Lecture Series, Peers within Field., Webinar (Mar 2015) Bowman AS Frequent movement of US exhibition swine impacts influenza A virus dynamics Presenter NIAID Centers of Excellence for Influenza Research and Surveillance Lecture Series International
  • Bowman AS, Presenter. "What’s Best for the Animal?." Presented at 2015 American Pre-Veterinary Medical Association National Symposium, Students., Columbus, Ohio, United States. (Mar 2015) Bowman AS What’s Best for the Animal? Presenter 2015 American Pre-Veterinary Medical Association National Symposium National
  • Bowman AS, Presenter. "Recent Advances with Swine Enteric Coronavirus Diseases." Presented at Midwest Veterinary Conference, Other., Columbus, Ohio, United States. (Feb 2015) Bowman AS Recent Advances with Swine Enteric Coronavirus Diseases Presenter 3 Midwest Veterinary Conference Regional